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Blood in the urine difficult or painful urination changes in mood such as depression forgetfulness signs of anaemiasuch as tirednessbeing short of breathand looking pale signs of frequent or worrying infections such as feversevere chillssore throat or mouth ulcers bruising or bleeding more easily than normalnose bleeds fainting skin rashitchiness pinkishitchy swellings on the skinalso called hives or nettle rash numbness or tingling in the hands or feet signs of melanomasuch as new skin spots or changes to the sizeshapecolour or edges of an existing skin spotfreckle or mole.

Your doctor may have prescribed SINEMET for another reasonAsk your doctor if you have any questions about why SINEMET has been prescribed for you.

SINEMET and iron salts or multivitamins containing iron salts should be coadministered with cautionIron salts can form chelates with levodopa and carbidopa and consequently reduce the bioavailability of carbidopa and levodopa.

Blood in the urine difficult or painful urination changes in mood such as depression forgetfulness signs of anaemiasuch as tirednessbeing short of breathand looking pale signs of frequent or worrying infections such as feversevere chillssore throat or mouth ulcers bruising or bleeding more easily than normalnose bleeds fainting skin rashitchiness pinkishitchy swellings on the skinalso called hives or nettle rash numbness or tingling in the hands or feet signs of melanomasuch as new skin spots or changes to the sizeshapecolour or edges of an existing skin spotfreckle or mole.

Patients should be advised that occasionallydark colorredbrownor blackmay appear in salivaurineor sweat after ingestion of SINEMETAlthough the color appears to be clinically insignificantgarments may become discolored.

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