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Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neuronsPharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activityThis interference with the reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.

For Interstitial Cystitis39 years oldThe 1st few daysno changeUrologist put me on 25 mgtwice a dayit made me so drowsythirstyonly took 1 pill at nighton the 14th day is when I had no more pressure or frequency on my bladderI was back to normalso I made the mistake of drinking coffeehuge mistakeTook medication the next daythis time morningnightsymptoms disappearedI suggest taking Prelief before drinking coffee or any acidic foodbe patient with this medicinetakes a little while to work but IT WORKS

Do not stop using Elavil suddenlyor you could have unpleasant withdrawal symptomsAsk your doctor how to safely stop using Elavil.

Drowsinessdizzinessdry mouthblurred visionconstipationweight gainor trouble urinating may occurIf any of these effects persist or worsennotify your doctor or pharmacist promptly.

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