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Some mixtures of medications can lead to serious and even fatal consequences.

Risk factors for arterial vascular diseasee.ghypertensiondiabetes mellitustobacco usehypercholesterolemiaand obesityand/or venous thromboembolisme.gpersonal history or family history of VTEobesityand systemic lupus erythematosusshould be managed appropriately.

2If you have a uterustalk to your healthcare provider about whether the addition of a progestin is right for you.

Clinical surveillance of all women taking estrogen/progestin combinations is importantsee PRECAUTIONSAdequate diagnostic measuresincluding endometrial sampling when indicatedshould be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleedingThere is no evidence that the use of natural estrogens results in a different endometrial risk profile than synthetic estrogens of equivalent estrogen doseAdding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasiawhich may be a precursor to endometrial cancer.

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