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Adverse reactions to corticosteroids may be produced by too rapid withdrawal or by continued use of large doses.

Adequate studies have not been performed in animals to determine whether fludrocortisone acetate has carcinogenic or mutagenic activity or whether it affects fertility in males or females.

Corticosteroids may mask some signs of infectionand new infections may appear during their useThere may be decreased resistance and inability to localize infection when corticosteroids are usedIf an infection occurs during fludrocortisone acetate therapyit should be promptly controlled by suitable antimicrobial therapy.

Dosage depends on the severity of the disease and the response of the patientPatients should be continually monitored for signs that indicate dosage adjustment is necessarysuch as remissions or exacerbations of the disease and stresssurgeryinfectiontraumasee WARNINGS and PRECAUTIONSGeneral

Pregnancy and breastfeeding If you are pregnant or breastfeedingthink you may be pregnant or are planning to have a babyask your doctor or pharmacist for advice before taking this medicine.

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