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Mosaic tetracycline resistance genes are widespread in human and animal fecal samples.

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There are three naturally occurring tetracyclinesoxytetracyclinechlortetracyclineand demethylchlortetracyclineand several that are derived semisyntheticallytetracyclinerolitetracyclinemethacyclineminocyclinedoxycyclinelymecyclineetcElimination times permit a further classification into short-actingtetracyclineoxytetracyclinechlortetracyclineintermediate-actingdemethylchlortetracycline and methacyclineand long-actingdoxycycline and minocyclineThe newest class of tetracyclinerelated antimicrobials are the glycylcyclinesrepresented by tigecyclinewhich contains a bulky side chain compared with minocycline

Avoid exposure to sunlight or artificial UV rayssunlamps or tanning bedsTetracycline can make your skin more sensitive to sunlight and sunburn may resultUse a sunscreenminimum SPF 15and wear protective clothing if you must be out in the sun.

Tetracyclines are in pregnancy category Dthere is evidence of human riskbut clinical benefits may outweigh riskTetracyclines cross the placentaenter fetal circulationaccumulate in fetal bonesandif used during the 2nd or 3rd trimestermay cause permanent discoloration of teeth.

If you develop side affectsadvise your doctorYou may need to stop taking the tetracycline or change brand.

The tetracyclines are broad-spectrum antibiotics with similar antimicrobial featuresbut they differ somewhat from one another in terms of their spectra and pharmacokinetic disposition.

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