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Patients with rheumatoid arthritis previously treated with alkylating agents cyclophosphamide, chlorambucil, melphalan, or others may have a prohibitive risk of malignancy if treated with imuran.

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Store at room temperatureStore in a dry placeDo not store in a bathroomProtect from lightKeep all drugs in a safe placeKeep all drugs out of the reach of children and petsThrow away unused or expired drugsDo not flush down a toilet or pour down a drain unless you are told to do soCheck with your pharmacist if you have questions about the best way to throw out drugsThere may be drug take-back programs in your area.

IMURAN should not be given to patients who have shown hypersensitivity to the drugIMURAN should not be used for treating rheumatoid arthritis in pregnant womenPatients with rheumatoid arthritis previously treated with alkylating agentscyclophosphamidechlorambucilmelphalanor othersmay have a prohibitive risk of malignancy if treated with IMURAN.

There is in vitro evidence that aminosalicylate derivativese.gsulphasalazinemesalazineor olsalazineinhibit the TPMT enzymeConcomitant use of these agents with IMURAN should be done with caution.

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