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Olanzapine may increase prolactin levelsIncreased prolactin levels may manifest as abnormal menstruationsexual dysfunctionand breast enlargement.

Certain portions of the discussion below relating to objective or numeric safety parametersnamelydose-dependent adverse reactionsvital sign changesweight gainlaboratory changesand ECG changes are derived from studies in patients with schizophrenia and have not been duplicated for bipolar I disordermanic or mixed episodesor agitationHoweverthis information is also generally applicable to bipolar I disordermanic or mixed episodesand agitation.

DisclaimerOur goal is to provide you with the most relevant and current informationHoweverbecause drugs interact differently in each personwe cannot guarantee that this information includes all possible interactionsThis information is not a substitute for medical adviceAlways speak with your healthcare provider about possible interactions with all prescription drugsvitaminsherbs and supplementsand over-the-counter drugs that you are taking.

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olanzapine clearance is about 40 higher in smokers than in nonsmokers, although dosage modifications are not routinely required.

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