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Clozaril treatment has caused severe neutropenia, defined as an absolute neutrophil count anc less than 500 l.

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Tight feeling in your neck or jawtwitching or uncontrollable movements of your eyeslipstonguefacearmsor legs;

Because of the risks associated with Clozarilits use is limited to patients in whom therapy is indicated as set out in section 4.1 and:

This medication may pass into breast milk and have undesirable effects on a nursing infantBreast feeding is not recommended while taking clozapineConsult your doctor before breast-feeding.

Prescribing physicians must comply fully with the required safety measuresAt each consultationa patient receiving Clozaril must be reminded to contact the treating physician immediately if any kind of infection begins to developParticular attention must be paid to flu-like complaints such as fever or sore throat and to other evidence of infectionwhich may be indicative of neutropeniasee section 4.4

Cases have been reported of an interaction between citalopram and clozapinewhich may increase the risk of adverse events associated with clozapineThe nature of this interaction has not been fully elucidated.

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other members of this class include clozapine clozaril , risperidone risperdal , aripiprazole abilify and ziprasidone geodon .

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