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Rhabdomyolysis has been observed in patients experiencing skin and/or liver reactions associated with Viramune use.

The predetermined primary efficacy comparison was between the Viramune twice daily and the efavirenz treatment groups.

It is not recommended to co-administer ketoconazole and Viramunesee section 4.4

No clinical data availableDue to the metabolic pathway of raltegravir no interaction is expected.

In some caseshepatic injury has progressed despite discontinuation of treatmentPatients developing signs or symptoms of hepatitissevere skin reaction or hypersensitivity reactions must discontinue nevirapine and seek medical evaluation immediatelyNevirapine must not be restarted following severe hepaticskin or hypersensitivity reactionssee section 4.3

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