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Because of the risk of disseminated intravascular coagulation with use of celebrex in pediatric patients with systemic onset jra, monitor patients for signs and symptoms of abnormal clotting or bleeding, and inform patients and their caregivers to report symptoms as soon as possible.

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Advise patients to stop CELEBREX immediately if they develop any type of rash and to contact their healthcare provider as soon as possiblesee WARNINGS AND PRECAUTIONS

What is the most important information I should know about medicines called Nonsteroidal Anti-inflammatory DrugsNSAIDs

In controlled clinical trialselevated BUN occurred more frequently in patients receiving CELEBREX compared with patients on placeboThis laboratory abnormality was also seen in patients who received comparator NSAIDs in these studiesThe clinical significance of this abnormality has not been established.

This list is not completeOther drugs may interact with celecoxibincluding prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guide.

CELEBREX is approved for relief of the signs and symptoms of Juvenile Rheumatoid Arthritis in patients 2 years and olderSafety and efficacy have not been studied beyond six months in childrenThe long-term cardiovascular toxicity in children exposed to CELEBREX has not been evaluated and it is unknown if long-term risks may be similar to that seen in adults exposed to CELEBREX or other COX-2 selective and nonselective NSAIDssee BOXED WARNINGWARNINGS AND PRECAUTIONSand Clinical Studies

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